This paper further extends the existing cost modelfor a fixed-life perishable product in a two-echelon inventoryproblem into the net profit model. The extended model issubsequently evaluated by comparing its results with thoseobtained from OptQuest, a commercial simulationoptimizationpackage. Within a limited but reasonable time,the comparative results do not show a significantimprovement of using OptQuest, but do confirm that theproposed model can already provide quite good quality ofinventory control parameters for this system in a muchshorter computational time. With some simple modificationsto the proposed model, the model for slow-moving Poissondemand distribution for the two-echelon system is alsodeveloped and subsequently evaluated. The comparativeresults show that for the slow-moving demand, the Poissonmodel is more effective than the model with normalityassumption.