Under today’s volatile business environment, companies are reaching the point where they need to be more agile – intelligent,fast, flexible, and responsive to changes. Leveraging supplier-buyer relationships to create agile supply chains is one of the strategies thatcan help companies make a successful transition to an agile enterprise. Under this new paradigm shift, companies need a new set of toolsand methodologies to dynamically choose suppliers in order to maintain their competitive advantage. The goal of this research is to addressthis need by developing a comprehensive framework for evaluating suppliers’ agile performance. Two new sets of metrics, “changeresponse proficiency” and “Agility intangible infrastructure,” are introduced. The first one addresses the ability of suppliers to respond toeach specific change by considering the balance point across four dimensions, which are time, cost, robustness and scope. The second oneaddresses the organizational skills, information and knowledge and corporate culture that help companies enable their ability to respond tochanges quickly and efficiently. Our model, based on Analytic Hierarchy Process (AHP) techniques, is developed and employed in thisresearch to identify and prioritize the required metrics. This comprehensive framework builds upon the concepts developed through theAgility Program at Lehigh University in partnership with company project sponsors and the Commonwealth of Pennsylvania Departmentof Community and Economic Development. A real-life case study is used to illustrate the application of this new framework.