This paper investigates the vehicle routing problem with manual materials handling (VRPMMH). Briefly, when a delivery vehicle arrives at the customer, delivery crew must move selected goods from the vehicle to the customer’s stock room. Knowing the number of customers, required workloads, and number of vehicles, the problem objective is to determine ergonomic work schedules of the delivery crew such that their daily energy expenditure will not exceed the recommended level (i.e., 33% of the energy capacity). Mathematical models for the VRPMMH are developed to find a minimum number of utilized vehicles, their delivery route, and daily work schedules (the number of customers to be served en route) of the crew such that a maximum daily energy expenditure is minimized.