Many educational institutions nowadays have increasingly integrated e-learning technologies into their educational system to better serve the needs of their students and to best prepare them for the challenges they face in the modern world. This is because e-learning can create and deliver a rich learning environment, which in turn enhances students’ academic performance. By integrating appropriate adaptive technologies and disabilities and high-potential students, respectively, can also significantly benefit from an e-learning experience the same as other students. This paper aims at adapting UTCC Hybrid Learning infrastructure to design a learning framework for disabled and high-potential students. Accordingly, the authors discuss the benefits of e-learning, describe UTCC Hybrid Learning infrastructure and implementation, and put forward Hybrid Learning frameworks for both disabled and high-potential students.